Ubiquitously used as a protest of an unjust killing, die-ins have been used to protest mass shootings in the United States. In 2015, a die-in was famously staged on the front steps of the United States Capital building on the National Mall for 720 seconds, one second for every person killed in mass shootings in the previous 2 years. The protest came on the second anniversary of the Pulse Nightclub shooting. In a similar protest of gun violence in America, March for our Lives co-founder David Hogg staged a collective die-in outside of Publix Supermarkets in Florida due to their donations towards pro-gun gubernatorial candidate Peter Putnam, leading to Publix' suspension of all contributions to Putnam's campaign the same day.

In protest of the killing of George Floyd and other victims of police brutaliy, a large group of healthcare workers staged a die-in at the Trinity Skyline Trail in North Dallas for eight minutes and forty-six seconds, the time that the police officer kept his knee on Floyd's neck. The die-in itself began as a motion of solidarity with an open letter from medical professionals at the University of Washington who agreed on systemic racism being defined as a public health issue. These protesters additionally used their career positions to request the government to not crack down on the protests under the likeness of public health. Each of these demands were made clear with their use of their physical bodies to lay down on the trail, captured by news organizations and thus giving a voice to themselves.